Environmental exposures in utero and microRNA

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Environmental exposures in utero and microRNA

PURPOSE OF REVIEW Understanding the effects of in-utero exposures to environmental agents is of great importance as the resulting deregulation of biological processes can affect both fetal development and health outcomes that manifest later in life. Due to their established role in developmental processes and inherent stability ex vivo, microRNAs (miRNAs) have emerged as attractive candidates t...

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In utero exposures to environmental organic pollutants disrupt epigenetic marks linked to fetoplacental development

While the developing fetus is largely shielded from the external environment through the protective barrier provided by the placenta, it is increasingly appreciated that environmental agents are able to cross and even accumulate in this vital organ for fetal development. To examine the potential influence of environmental pollutants on the placenta, we assessed the relationship between polybrom...

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Epigenetics and environmental exposures.

It is becoming increasingly apparent that genetic factors are inadequate to fully explain many processes that shape development and disease. For example, monozygotic twin pairs, despite sharing identical DNA sequences, are often discordant for many traits and diseases, indicating that the same genotype can give rise to distinct phenotypes. This points towards the involvement of additional facto...

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In utero radionuclide exposures and risk of leukaemia

Ionising radiation is a known leukaemogen and in utero exposure to diagnostic X-rays associates with increased risk of childhood leukaemia (see abstract by R. Wakeford). This paper examines the methodology used by the International Commission on Radiological Protection (ICRP) to estimate doses to the child following in utero radionuclide exposures, considers experimental evidence for in utero h...

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Environmental Exposures and Hepatocellular Carcinoma

Infection with hepatitis B and/or hepatitis C virus is a well-established risk factor for the development of hepatocellular carcinoma (HCC). However, it is now clear that certain occupational, environmental, and lifestyle factors also play a role in cancer development. Among these factors are smoking, alcohol consumption, workplace exposure to vinyl chloride, and exposure to polycylic aromatic ...

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ژورنال

عنوان ژورنال: Current Opinion in Pediatrics

سال: 2014

ISSN: 1040-8703

DOI: 10.1097/mop.0000000000000073